Output Biosciences · New York City
OtherEngineeringFullTimeposted 6w ago
Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one.
Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.
You will lead the design and development of Output's generative models, working across molecular modalities to build systems that produce novel, biologically grounded molecules. This role spans the full arc from research to trained model: you design architectures, develop training approaches, run experiments on distributed GPU clusters, and evaluate results.
You will design and build generative architectures for molecular data spanning multiple modalities, including small molecules, peptides, mini proteins and more
You will develop training approaches that learn from diverse biological signal, ensuring the model composes genuinely novel structures
You will build methods for controllable, targeted generation, enabling the model to produce molecules with specified biological properties while satisfying real-world chemical constraints
You will integrate biological reasoning from our foundation model into the generative pipeline, using learned biological representations to guide and condition generation
You will own training end-to-end: experiment design, distributed training on multi-GPU clusters, hyperparameter optimization, and iteration
You will design evaluation frameworks that go beyond statistical metrics to measure whether generated molecules are biologically meaningful, structurally valid, and genuinely novel
About You
You have a PhD in computer science, machine learning, physics, mathematics, or a related field with 2+ years of post-doctoral or industry research experience, or a Bachelor's or Master's degree with 5+ years of hands-on research and engineering experience in generative modeling
You have a strong publication record in generative methods at top-tier venues (e.g., NeurIPS, ICML, ICLR)
You have extensive hands-on experience designing, building, and training deep generative models, including work on novel architectures, training objectives, or sampling methods
You are proficient in Python and PyTorch, and have experience training models on distributed multi-GPU infrastructure
You have demonstrated the ability to own the full research-to-training pipeline: you do not just design methods, you train and ship models
You write production-quality code that is well-tested and maintainable, and you are comfortable working in shared codebases with version control and code review
You are a rigorous experimentalist who designs evaluations carefully, tracks experiments systematically, and draws conclusions from data
Bonus Points
You have experience applying generative models to molecular, chemical, or biological data
You have a background in chemistry, biology, computational biology, biophysics, or a related natural science
You have experience with multi-modal learning or cross-modality translation
You have experience with conditional or controllable generation methods
You have contributed to open-source machine learning projects
❤️ Heart: We foster a culture of ownership. We are assembling a team of individuals who are passionate and take pride in their contributions.
🏆 Excellence: We have an unwavering commitment to excellence and continuously challenge ourselves to reach the highest standards.
🚀 Practicality: We value practicality and results-oriented thinking. We are committed to making a tangible impact on the lives of patients and the broader community.
📣 Honesty: We place a high value on honesty and directness. We firmly believe in addressing issues as they arise, in an open and transparent manner.
🎮 Fun: We believe that life is too short to not have fun. Our goal is to create a workplace that is fun, engaging, rewarding and fulfilling.
We encourage new and different ideas, creativity and contrarian thinking
Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you
You own your day-to-day management. What we care about is that we all hit our milestones
Competitive salary and equity in a growing, well-funded startup
Excellent medical, dental, and vision coverage